The matchup between the Kentucky Wildcats and Louisville Cardinals is one of the best rivalries in college basketball. Louisville has had its fair share of struggles over the last handful of years, but Pat Kelsey has brought the Cards back to national relevance.

The Wildcats will take on the Cardinals in Louisville, as their mid-November matchup is slated to be played in the KFC Yum! Center. No time has been set for the game, although it's safe to assume the major rivalry matchup between two NCAA Tournament teams will be on primetime.

The 2025-26 meeting between Kentucky and Louisville will take place much earlier on the schedule than past games in the basketball rivalry.