Lionel Messi and Inter Miami were handed their most devastating loss since the Argentine star joined the MLS, falling 4-1 to Minnesota United in a collapse that exposed growing cracks in the club's form.

Lionel Messi and Inter Miami are out of the 2025 Concacaf Champions Cup following Wednesday's stunning 3-1 home loss to the Cinderella Vancouver Whitecaps.

Lionel Messi was powerless to prevent Inter Miami from slipping to its biggest defeat in MLS play since his arrival in North America, falling 4-1 at Minnesota United on Saturday. Previously, there had only been one two-goal defeat with Messi — a 1-3 home loss to Atlanta United in May last year.